external control
Incorporating External Controls for Estimating the Average Treatment Effect on the Treated with High-Dimensional Data: Retaining Double Robustness and Ensuring Double Safety
Dai, Chi-Shian, Ying, Chao, Ning, Yang, Zhao, Jiwei
Randomized controlled trials (RCTs) are widely regarded as the gold standard for causal inference in biomedical research. For instance, when estimating the average treatment effect on the treated (ATT), a doubly robust estimation procedure can be applied, requiring either the propensity score model or the control outcome model to be correctly specified. In this paper, we address scenarios where external control data, often with a much larger sample size, are available. Such data are typically easier to obtain from historical records or third-party sources. However, we find that incorporating external controls into the standard doubly robust estimator for ATT may paradoxically result in reduced efficiency compared to using the estimator without external controls. This counterintuitive outcome suggests that the naive incorporation of external controls could be detrimental to estimation efficiency. To resolve this issue, we propose a novel doubly robust estimator that guarantees higher efficiency than the standard approach without external controls, even under model misspecification. When all models are correctly specified, this estimator aligns with the standard doubly robust estimator that incorporates external controls and achieves semiparametric efficiency. The asymptotic theory developed in this work applies to high-dimensional confounder settings, which are increasingly common with the growing prevalence of electronic health record data. We demonstrate the effectiveness of our methodology through extensive simulation studies and a real-world data application.
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- Research Report > Strength High (1.00)
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- Health & Medicine > Therapeutic Area (0.93)
- Health & Medicine > Health Care Technology > Medical Record (0.54)
Toward RAPS: the Robot Autonomy Perception Scale
Silva, Rafael Sousa, Smith, Cailyn, Bezerra, Lara, Williams, Tom
Human-robot interactions can change significantly depending on how autonomous humans perceive a robot to be. Yet, while previous work in the HRI community measured perceptions of human autonomy, there is little work on measuring perceptions of robot autonomy. In this paper, we present our progress toward the creation of the Robot Autonomy Perception Scale (RAPS): a theoretically motivated scale for measuring human perceptions of robot autonomy. We formulated a set of fifteen Likert scale items that are based on the definition of autonomy from Beer et al.'s work, which identifies five key autonomy components: ability to sense, ability to plan, ability to act, ability to act with an intent towards some goal, and an ability to do so without external control. We applied RAPS to an experimental context in which a robot communicated with a human teammate through different levels of Performative Autonomy (PA): an autonomy-driven strategy in which robots may "perform" a lower level of autonomy than they are truly capable of to increase human situational awareness. Our results present preliminary validation for RAPS by demonstrating its sensitivity to PA and motivate the further validation of RAPS.
Polyffusion: A Diffusion Model for Polyphonic Score Generation with Internal and External Controls
Min, Lejun, Jiang, Junyan, Xia, Gus, Zhao, Jingwei
ABSTRACT We propose Polyffusion, a diffusion model that generates polyphonic music scores by regarding music as imagelike piano roll representations. The model is capable of controllable music generation with two paradigms: internal control and external control. We show that by using tive modeling [14,15], symbolic music generation still suffers internal and external controls, Polyffusion unifies a from the lack of controllability and consistency at different wide range of music creation tasks, including melody generation time scales [16]. In our study, we experiment with given accompaniment, accompaniment generation the idea of using diffusion models to approach controllable given melody, arbitrary music segment inpainting, and music symbolic music generation. Experimental results Inspired by the high-quality and controllable image show that our model significantly outperforms existing generation that diffusion models have achieved in computer Transformer and sampling-based baselines, and using vision, we devise an image-like piano roll format as pre-trained disentangled representations as external conditions the input, and used a UNet-based diffusion model to stepwise yields more effective controls.
- Media > Music (1.00)
- Leisure & Entertainment (1.00)
A Causal Inference Framework for Leveraging External Controls in Hybrid Trials
Valancius, Michael, Pang, Herb, Zhu, Jiawen, Cole, Stephen R, Funk, Michele Jonsson, Kosorok, Michael R
We consider the challenges associated with causal inference in settings where data from a randomized trial is augmented with control data from an external source to improve efficiency in estimating the average treatment effect (ATE). Through the development of a formal causal inference framework, we outline sufficient causal assumptions about the exchangeability between the internal and external controls to identify the ATE and establish the connection to a novel graphical criteria. We propose estimators, review efficiency bounds, develop an approach for efficient doubly-robust estimation even when unknown nuisance models are estimated with flexible machine learning methods, and demonstrate finite-sample performance through a simulation study. To illustrate the ideas and methods, we apply the framework to a trial investigating the effect of risdisplam on motor function in patients with spinal muscular atrophy for which there exists an external set of control patients from a previous trial.
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- Europe > United Kingdom > England > Oxfordshire > Oxford (0.14)
- North America > United States > North Carolina > Orange County > Chapel Hill (0.04)
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- Research Report > Experimental Study (1.00)